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Talk Python To Me

A podcast on Python and related technologies


Latest episode:
#527 MCP Servers for Python Devs

Today we’re digging into the Model Context Protocol, or MCP. Think LSP for AI: build a small Python service once and your tools and data show up across editors and agents like VS Code, Claude Code, and more. My guest, Den Delimarsky from Microsoft, helps build this space and will keep us honest about what’s solid versus what's just shiny. We’ll keep it practical: transports that actually work, guardrails you can trust, and a tiny server you could ship this week. By the end, you’ll have a clear mental model and a path to plug Python into the internet of agents.
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Den Delimarsky
Den Delimarsky

Take Python to the next level with our online courses

Upcoming episodes

David Kopec
David Kopec
(up next)
Computer Science from Scratch

A lot of people building software today never took the traditional CS path. They arrived through curiosity, a job that needed automating, or a late-night itch to make something work. This week, David Kopec joins me to talk about rebuilding computer science for exactly those folks, the ones who learned to program first and are now ready to understand the deeper ideas that power the tools they use every day.

Vincent D. Warmerdam
Vincent D. Warmerdam
(and then)
Python apps with LLM building blocks

In this episode, I’m talking with Vincent Warmerdam about treating LLMs as just another API in your Python app, with clear boundaries, small focused endpoints, and good monitoring. We’ll dig into patterns for wrapping these calls, caching and inspecting responses, and deciding where an LLM API actually earns its keep in your architecture.

Trevor Manz
Trevor Manz
(finally)
anywidget: Jupyter Widgets made easy

For years, building interactive widgets in Python notebooks meant wrestling with toolchains, platform quirks, and a mountain of JavaScript machinery. Most developers took one look and backed away slowly. Trevor Manz decided that barrier did not need to exist. His idea was simple: give Python users just enough JavaScript to unlock the web’s interactivity, without dragging along the rest of the web ecosystem. That idea became anywidget, and it is quickly becoming the quiet connective tissue of modern interactive computing. Today we dig into how it works, why it has taken off, and how it might change the way we explore data.

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Python Bytes Podcast

Python Bytes Podcast

Do you enjoy Talk Python To Me? We created a second podcast to be the perfect counterpart to the long-form interview format on Talk Python:

Python Bytes:
Python headlines delivered directly to your earbuds


If you are looking for a 15 minute conversation on the topical items of the week in the Python ecosystem, be sure to jump over to Python Bytes and subscribe.

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More about Talk Python to Me

Talk Python to Me is a weekly podcast hosted by Michael Kennedy. The show covers a wide array of Python topics as well as many related topics.

The format is a casual 1-hour conversation with industry experts.

Have feedback for the show? Send it to contact@talkpython.fm. We'd love to hear from you.

Michael Kennedy
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Michael Kennedy

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We are always on the look out for exciting topics to bring to you on Talk Python To Me. We could use your help!

Do you have a great idea for a show? Do know a dynamic Python personality who we should be speaking to? Send us an email!


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