New course: Agentic AI for Python Devs

Talk Python To Me

A podcast on Python and related technologies


#1
Python Podcast
11+
Years Running
50M+
Downloads

Latest episode: #546 Self hosting apps for Python people

The cloud is convenient until it isn't. You upload your photos, sync your contacts, click through the cookie banners. Then prices go up again or you read about a family that lost their entire Google account over a medical photo sent to a doctor. At some point, the question shifts from "why would I run this myself?" to "why aren't I?"

My guest this week is Alex Kretzschmar, head of DevRel at Tailscale, longtime host of the Self-Hosted podcast, and co-founder of Linuxserver.io. We cover what self-hosting really means in 2026, the apps worth running yourself like Immich and Home Assistant, why Docker Compose ties it all together, and how Tailscale lets you reach any of it from anywhere, without opening a single port. If you've been thinking about pulling your digital life back behind your own walls, this is your roadmap.

Upcoming episodes

Panelists
Panelists
(up next)
Parallel Python at Any Scale with Ray

When OpenAI trained GPT-3, they didn't roll their own orchestration layer. They used Ray, an open source Python framework born out of the same Berkeley research lab lineage that gave us Apache Spark. And here's the twist: Ray was originally built for reinforcement learning research, then quietly faded as RL hit a wall. Until ChatGPT showed up. Suddenly reinforcement learning was back, as the post-training step that turns a raw language model into something genuinely useful.

Edward Oakes and Richard Laiw, two founding engineers behind Ray and AnyScale, join me on Talk Python to tell that story. We'll trace Ray from its RISE Lab origins at UC Berkeley to powering some of the largest training runs in the world. We'll talk about what Ray actually is, a distributed execution engine for AI workloads, and how a few lines of Python become work running across hundreds of GPUs. We'll cover Ray Data for multimodal pipelines, the dashboard, the VS Code remote debugger, KubRay for Kubernetes, and where Ray fits alongside Dask, multiprocessing, and asyncio.

If you've ever stared at a single-machine Python script and thought, "there has to be a better way to scale this", this one's for you

Chris May
Chris May
(and then)
Event Sourcing Design Pattern

Michael Booth
Michael Booth
(finally)
Hyper-Personal Software with Python

Stay connected with Talk Python

Listen for Free

Add Talk Python to your favorite podcast player and never miss an episode.

Subscribe Now

Join the Newsletter

Get episode updates, Python news, and exclusive content delivered to your inbox.

Subscribe to Newsletter

Talk Python changed my career

From career changes to breakthrough moments, hear how the podcast has made a real impact.

"The podcast has been a wealth of information and has positively contributed to my efforts to learn Python. Frankly, the podcast is the best way I've found to augment the training videos, documentation, and books I've used to learn the language."
— Dennis M.
"This is the podcast that got me into listening to nearly only technical ones. All the episodes are fun and informative, and I can't recommend it enough for every Pythonista."
— Nikola Kantar
"Each and every episode, I learn at least one thing that motivates me to change my day to day life."
— Ronak15

Feedback on the show

Love it
It is really superb in all aspects
— czerpi
Great Python Podcast
Great pick if you need to catch up on Python!
— Prokke
Amazing
I have learned so much because of this podcast!
— Marius Longsword
Do you love the show and want to tell the world? Send us a review or post one on iTunes. Thanks!

Take Python to the next level

Online courses from Talk Python. Real courses with real coding helping you build production-ready skills.

Training for teams

Looking to level up your entire team's Python skills? Talk Python Training offers bulk discounts for organizations, plus an admin dashboard to track team progress and completion.

Learn about team plans
Talk Python for Production book cover by Michael Kennedy

From the creator of Talk Python

Python for Production

Learn how to build, deploy, and scale production-ready Python applications. From best practices to real-world patterns, this book covers everything you need to take your Python projects from prototype to production.

Wondering if we cover a topic?

Search across 547+ episodes to find exactly what you're looking for.

Search episodes

Python Bytes Podcast

Do you enjoy Talk Python To Me? We created a second podcast to be the perfect counterpart to the long-form interview format.

Python Bytes delivers Python headlines directly to your earbuds in just 15-20 minutes per week. The topical items of the Python ecosystem, condensed and ready to go.

Michael Kennedy
Michael Kennedy
Your Host

About the Show

Talk Python to Me is a weekly podcast covering a wide array of Python topics as well as many related technologies. Each episode features a casual 1-hour conversation with industry experts.

Have feedback for the show? We'd love to hear from you.

Suggest a podcast guest

Suggest a show or guest

We are always on the look out for exciting topics to bring to you on Talk Python To Me. Do you have a great idea for a show? Know a dynamic Python personality who we should be speaking to?

Ready to learn from the best minds in Python?

Talk Python's Mastodon Michael Kennedy's Mastodon