New course: Agentic AI for Python Devs

Talk Python To Me

A podcast on Python and related technologies


#1
Python Podcast
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Latest episode: #552 Astral joins OpenAI

OpenAI just acquired Astral, the company behind uv, Ruff, and ty. And if your first thought was "wait, is uv toast?", you are not alone. But here's the twist Charlie Marsh shared with me: he thinks they may ship more open source at OpenAI than they ever did at Astral. On this episode, we get into the acquisition, the mixed feelings, the future of your favorite Python tools, and what it's like to build right at the center of the AI universe.

Upcoming episodes

Calvin Hendryx-Parker
Calvin Hendryx-Parker
(up next)
All of our tools (cross-over)

Sumit Gundawar
Sumit Gundawar
(and then)
Trustworthy AI in Healthcare and Longevity

Trevor Manz
Trevor Manz
(finally)
Marimo Pair - A Canvas for Agent + Developers Collaboration

Coding agents have gotten really good at one kind of work. You scope a feature, edit some files, run the tests, ship it. It all happens on disk. But that is not how data work feels. You load something, you look at it, you run a cell, you watch how it responds, and you decide the next move from whatever is sitting in memory. And until now, your agent couldn't see any of that. It only saw the files. Never the live state.

This episode, that wall comes down. marimo pair drops a coding agent right inside a running notebook, with full access to every variable Python is holding in memory. The notebook becomes a shared canvas. You point, it runs the code. You tell it to zoom in on the Picasso paintings, and the chart just updates. No MCP tools to wire up, no schema to describe. Just Python, and an agent that can finally see what you see. Trevor Manz is back to walk us through it.

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Python Bytes delivers Python headlines directly to your earbuds in just 15-20 minutes per week. The topical items of the Python ecosystem, condensed and ready to go.

Michael Kennedy
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About the Show

Talk Python to Me is a weekly podcast covering a wide array of Python topics as well as many related technologies. Each episode features a casual 1-hour conversation with industry experts.

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