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Talk Python To Me

A podcast on Python and related technologies


#1
Python Podcast
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Latest episode: #551 Stroll Down Startup Lane - 2026

If you've ever been to PyCon, you know one of the best parts of the expo hall is Startup Row, a stretch of booths where early-stage companies built on Python show off what they're creating. But only attendees get to walk that lane, so let's bring it to everyone. In this episode, we stroll down Startup Row together. We kick things off with the organizers, Jason and Shay, who share the program's origin story going back to Paul Graham and the PSF, plus some surprising stats, including two unicorns among the alumni. Then we meet five startups: Tetrix, bringing AI to institutional investing in private markets. Arcjet, security that lives inside your app as an SDK. Phemeral.dev, serverless hosting built for Python web apps. CapiscIO, an identity and authority layer for AI agents. And Pixeltable, a multimodal database from Marcel Kornacker, co-creator of Apache Parquet. See if you can spot the theme running through them all. Let's go for a walk.

Upcoming episodes

Charlie Marsh
Charlie Marsh
(up next)
Astral joins OpenAI

Michael Booth
Michael Booth
(and then)
Hyper-Personal Software with Python

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Python Bytes Podcast

Do you enjoy Talk Python To Me? We created a second podcast to be the perfect counterpart to the long-form interview format.

Python Bytes delivers Python headlines directly to your earbuds in just 15-20 minutes per week. The topical items of the Python ecosystem, condensed and ready to go.

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About the Show

Talk Python to Me is a weekly podcast covering a wide array of Python topics as well as many related technologies. Each episode features a casual 1-hour conversation with industry experts.

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