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Talk Python To Me

A podcast on Python and related technologies


#1
Python Podcast
11+
Years Running
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Latest episode: #546 Self hosting apps for Python people

The cloud is convenient until it isn't. You upload your photos, sync your contacts, click through the cookie banners. Then prices go up again or you read about a family that lost their entire Google account over a medical photo sent to a doctor. At some point, the question shifts from "why would I run this myself?" to "why aren't I?"

My guest this week is Alex Kretzschmar, head of DevRel at Tailscale, longtime host of the Self-Hosted podcast, and co-founder of Linuxserver.io. We cover what self-hosting really means in 2026, the apps worth running yourself like Immich and Home Assistant, why Docker Compose ties it all together, and how Tailscale lets you reach any of it from anywhere, without opening a single port. If you've been thinking about pulling your digital life back behind your own walls, this is your roadmap.

Upcoming episodes

Panelists
Panelists
(up next)
Parallel Python at Any Scale with Ray

When OpenAI trained GPT-3, they didn't roll their own orchestration layer. They used Ray, an open source Python framework born out of the same Berkeley research lab lineage that gave us Apache Spark. And here's the twist: Ray was originally built for reinforcement learning research, then quietly faded as RL hit a wall. Until ChatGPT showed up. Suddenly reinforcement learning was back, as the post-training step that turns a raw language model into something genuinely useful.

Edward Oakes and Richard Laiw, two founding engineers behind Ray and AnyScale, join me on Talk Python to tell that story. We'll trace Ray from its RISE Lab origins at UC Berkeley to powering some of the largest training runs in the world. We'll talk about what Ray actually is, a distributed execution engine for AI workloads, and how a few lines of Python become work running across hundreds of GPUs. We'll cover Ray Data for multimodal pipelines, the dashboard, the VS Code remote debugger, KubRay for Kubernetes, and where Ray fits alongside Dask, multiprocessing, and asyncio.

If you've ever stared at a single-machine Python script and thought, "there has to be a better way to scale this", this one's for you

Chris May
Chris May
(and then)
Event Sourcing Design Pattern

Michael Booth
Michael Booth
(finally)
Hyper-Personal Software with Python

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"The podcast has been a wealth of information and has positively contributed to my efforts to learn Python. Frankly, the podcast is the best way I've found to augment the training videos, documentation, and books I've used to learn the language."
— Dennis M.
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— Nikola Kantar
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— Ronak15

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Consistently excellent content and great guests
Michael is one of the leading voices of the Python community. The content is always intriguing and a great way to stay motivated while learning. Keep up the great work!
— Ianbttlsian
A breathtakingly awesome podcast
Ending off the day by discovering a breathtakingly awesome podcast, the Talk Python To Me podcast covers the people and ideas in Python so well, I am extremely astounded and thankful.
— Joshua S.
I learn something new from each episode!
I love this podcast; never a dull moment. It was the first podcast that I ever listened to and now I'm hooked! My hour drive into work is no longer one where I struggle to stay awake!
— Clamytoe
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Python Bytes Podcast

Do you enjoy Talk Python To Me? We created a second podcast to be the perfect counterpart to the long-form interview format.

Python Bytes delivers Python headlines directly to your earbuds in just 15-20 minutes per week. The topical items of the Python ecosystem, condensed and ready to go.

Michael Kennedy
Michael Kennedy
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About the Show

Talk Python to Me is a weekly podcast covering a wide array of Python topics as well as many related technologies. Each episode features a casual 1-hour conversation with industry experts.

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